111-76-2) In Support of Summary Information on the . The major urinary metabolite was 2-(2-butoxyethoxy)acetic acid. Fischer 344 rats exposed for 9 days (6 hr/day) over an 11-day period, to 0 (control), 19, 41, or 84 ppm EGHE had decreased body weight gains and increased liver to body weight values at 84 ppm EGHE. Join ResearchGate to find the people and research you need to help your work. 2-Butoxyethanol has moderate acute toxicity and is irritating to the eyes and skin; it is not a skin sensitizer. Dose-dependent Michaelis-Menten kinetics in the elimination of EGBE were observed in the investigated concentration range. 111-76-2) is a high- production-volume glycol ether. Information on the peer review of this CICAD is presented in Appendix 2. High doses of ethylene glycol mono methyl ether (EGM), ethylene glycol mono methyl ether acetate (EGMA), ethylene glycol mono ethyl ether (EGE) and ethylene glycol mono ethyl acetate (EGEA) produced marked testicular atrophy and leucopenia. EPA has denied a petition to remove Ethylene Glycol Monobutyl Ether (EGBE) from the list of chemicals subject to reporting under section 313 of the Emergency Planning and Community Right-to-Know Act (EPCRA). Information on the nature of the peer review and availability of the source documents is presented in Appendix 1. eCollection 2020. At 41.1 ppm, maternal body weight gain was reduced during the exposure period only. The effects on the rat testis of single inhalation exposures to ethylene glycol monoalkyl ethers, in particular ethylene glycol monomethyl ether. A 14-day postexposure recovery showed substantial reversal of the affected blood parameters. Effects on peripheral blood, testes, and sperm have been reported at occupational exposure levels ranging between 0.4 and 10 ppm EGME in air, and with additional, possibly substantial, dermal exposure. NLM (ABSTRACT TRUNCATED AT 250 WORDS). On admission the 53-year-old patient was comatose with metabolic acidosis, shock, and noncardiogenic pulmonary edema confirmed by haemodynamic study. COVID-19 is an emerging, rapidly evolving situation. It is a colourless liquid that is miscible in water and soluble in most organic solvents. The available information on the acute and subchronic toxicity of ethylene glycol monobutyl ether is reviewed. The alkoxyacetic acid was a major metabolite for all three glycol ethers. Washington, DC The majority of the absorbed dose was excreted in the urine. This site needs JavaScript to work properly. It is also used in metal and household cleaners. Diethylene glycol (DEG) is a clear, colorless, odorless liquid with a sweet taste, and is an excellent solvent for water-insoluble chemicals and drugs. Arch Toxicol Suppl. Toxicity and death may occur after drinking even a small amount. Notice of Proposed Rulemaking Title 22, Section 12805 Specific Regulatory Levels Causing Reproductive Toxicity: ethylene glycol monoethyl ether (EGEE), ethylene glycol monoethyl ether acetate (EGEEA) and potassium dimethyldithiocarbamate 1984 Aug;57:7-12. doi: 10.1289/ehp.84577. Ethylene glycol monomethyl ether (EGME) and propylene glycol monomethyl ether (PGME): inhalation fertility and teratogenicity studies in rats, mice and rabbits. Environmental Health Perspectives Vol. Exposure of rodents to high concentrations of BE resulted in anemia due to hemolysis of blood cells, leukopenia, hemoglobinuria, and liver and kidney damage. EGMEA is rapidly converted to EGME in the body and the two substances are equally toxic in animals. It has many names including ethylene glycol monobutyl ether, ethylene glycol butyl ether, ethylene glycol n-butyl ether, Butyl Cellusolve, butyl glycol, and butyl Oxitol. Within the class of glycol ethers, the toxicity varies greatly. Nearly all air concentrations [MEA (n = 68), glycol ethers (n = 79), BA (n = 15), and formaldehyde (n = 45)] were far below (<1/10) of the corresponding Swiss occupational exposure limits (OEL), except for ethylene glycol mono-n-butyl ether (EGBE). Hepatic oxidative stress, up-regulation of pro-inflammatory cytokines, apoptotic and oncogenic markers following 2-methoxyethanol administrations in rats. Avoid contact with liquid. It attacks some forms of plastics, rubber and coatings. (1986). 112-25-4) for 6 hr/day on gestational days (gd) 6 through gd 15 (rats) or gd 6 through gd 18 (rabbits) at analytically measured concentrations (as means ± SD) of 20.8 ± 0.90, 41.1 ± 1.77, or 79.2 ± 10.8 ppm; control animals were exposed to air alone. Bulletin of Environmental Contamination and Toxicology. In several studies, increased frequency of spontaneous abortions, disturbed menstrual cycle, and subfertility have been demonstrated in women working in the semiconductor industry. Ethylene Glycol: The general formula for ethylene glycol is C 2 H 6 O 2. Data from animal studies have been examined from the standpoint of dose-response relationships and the sensitivity of various animal species, including man, to the effects of this chemical. Stability No data submitted 3.2. Concomitant administration of the alcohol dehydrogenase inhibitor 4-methylpyrazole with ME or MEA prevented suppression of the PFC response by these glycol ethers. The available information on the acute and subchronic toxicity of ethylene glycol monobutyl ether is reviewed. Owing to the short half-life of 2-butoxyethanol in the atmosphere, measured or predicted concentrations of this chemical in air are considered to have no environmental significance. Exposure to MEA was affected by its amount used (P = 0.036), and spraying (P = 0.000) and exposure to butoxypropanol was affected by spraying (P = 0.007) and cross-ventilation (P = 0.000). Participants at the Final Review Board meeting are listed in Appendix 3. Evaluation of workers exposed to ethylene glycol monomethyl ether and ethylene glycol monomethyl ether acetate. 2019 Oct-Dec;10(4):184-189. doi: 10.4103/japtr.JAPTR_57_19. As a relatively nonvolatile, inexpensive solvent, it is used in many domestic and industrial products because of its properties as a surfactant. Reproductive toxicity of the glycol ethers. The absorption of all three glycol ethers was approximately 20–25%, regardless of the chain length of the alkyl group or the dose administered. EGBE is manufactured by adding n-butyl alcohol and ethylene oxide. Ethylene glycol poisoning is poisoning caused by drinking ethylene glycol. ETHYLENE GLYCOL N-BUTYL ETHER may react with bases, aluminum and oxidizing materials. In general, administration in drinking water enhanced the production of ethylene glycol and glycol ether-derived CO2. Integrated Risk Information System (IRIS) March 2010 . Ethylene Glycol 107-21-1 Hazard Summary Ethylene glycol has many uses, including as antifreeze in cooling and heating systems, in hydraulic brake fluids, and as a solvent. DGBA (5 mM) was hydrolysed in rat blood to diethylene glycol monobutyl ether (DGBE) with a half-life of less than 3 min. 2-Butoxyethanol exists in the atmosphere almost entirely as a vapour; because the chemical has an atmospheric half-life of approximately 17 h, the risk for transport via the atmosphere should be small. A tolerable concentration of 0.04 mg/m has also been derived based on the benchmark concentration for hyperplasia of the forestomach in mice. Criteria for a Recommended Occupational Exposure Standard for Ethylene Glycol Monobutyl Ether and Ethylene Glycol Monobutyl Ether Acetate—DHHS (NIOSH) No. 3. The International Chemical Safety Card (ICSC 0059) produced by the International Programme on Chemical Safety (IPCS, 1993) has also been reproduced in this document. In addition to ME and MAA, only MEA, which was as effective as ME, suppressed the PFC response to TNP-LPS. Decreased body weight gains and increased liver weights were also found. 57, pp. 1983 Jun;27(2):91-102. doi: 10.1016/0300-483x(83)90014-8. Urine was collected for 24 h and analyzed for the metabolite butoxyacetic acid, also by gas chromatography. A. Mice were given various doses (62.5, 125, 250, 500, 1,000, 2,000 and 4,000 mg/kg body weight) of the compounds daily for 5 days/week, for 5 weeks. The results of in vitro studies indicate that human red blood cells are not as sensitive as rat red blood cells to the haemolytic effects of 2-butoxyethanol and 2-butoxyacetic acid and also that red blood cells are more sensitive to haemolysis by 2-butoxyacetic acid than to haemolysis by 2-butoxyethanol. review reported a dermal study carried out on 6 adult male rabbits. Toxicol Rep. 2020 Jun 23;7:779-787. doi: 10.1016/j.toxrep.2020.06.007. KRASAVAGE, W. J. The effects of ethylene glycol alkyl ethers on testis and embryotoxic effects of ethylene glycol monomethyl ether (EGM) have been studied, as has the teratogenicity of ethylene glycol dimethyl ether (EGdM). The presence of butoxyethanol in blood and of butoxyacetic acid in urine confirmed that butoxyethanol enters the systemic circulation in man in vivo during dermal exposure. Toxic doses being expressed as mg/kg body weight, esterification seemed to weaken the atrophic action of EGM and EGE, but when expressed as mol/kg, significant difference was found neither between EGM and EGMA nor between EGE and EGEA. Increased absolute and/or relative liver weights were observed in both sexes of the 71-ppm group and to a lesser extent in the 41-ppm group. Gestational parameters monitored were numbers of corpora lutea, preimplantation losses, viable implants, early and late resorptions, and dead fetuses. Three different amounts of the ¹⁴C-labeled glycol ethers (450–4000 μmole/kg) were applied to same-sized areas on the clipped backs of rats, and nonoccluded percutaneous absorption was measured. These 95% commercial antifreeze preparations are diluted ~50% with water when used in vehicle cooling systems. However, more realistic assumptions based on the available data suggest that risk to aquatic organisms is low. The percutaneous absorption of the commonly used glycol ether 2-butoxyethanol (ethylene glycol monobutyl ether) was investigated in 12 exposure experiments with five men. In animals, adverse effects on reproduction and development have not been observed at less than toxic doses. 2.-Butoxyethanol (CAS no. The elimination kinetics of 2-butoxyethanol (ethylene glycol monobutyl ether, EGBE) were studied in the once-through isolated perfused rat liver system in the presence and absence of ethanol. Based upon the development of haemolytic effects in pregnant rats exposed during gestation, a sample tolerable concentration for humans of 13.1 mg 2-butoxyethanol/m3 has been derived. Effects of repeated application of EGBE to the skin of rabbits. Access scientific knowledge from anywhere. Relatively little work has been done on the toxicity of organic arsenicals, especially the herbicide monosodium methanearsonate (MSMA). 2016 Dec;36(12):1614-1621. doi: 10.1002/jat.3326. The relationship between respiratory failure and EGBE is examined. Butyl Glycol Ether Revision Date 03/04/2015 Version 1.0 Print Date 03/04/2015 110000002553 Page 1 of 9 SAFETY DATA SHEET SECTION 1 IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING Trade name Butyl Glycol Ether Synonyms Butyl cellosolve, Ethylene glycol monobutyl ether 1984;7:167-70. doi: 10.1007/978-3-642-69132-4_23. All figure content in this area was uploaded by Tipton Tyler, All content in this area was uploaded by Tipton Tyler on Sep 25, 2015, ... More recent ocular tests in rabbits revealed that 30% and 70% concentrations of 2butoxyethanol were moderately irritating (Kennah et al., 1989). One animal in the RESULTS ETHYLENE GLYCOL MONOBUTYL ETHER 351 TABLE 1 SUBCHRONIC TOXICITY OF ETHYLENE GLYCOL MONOBUTYL ETHER SUMMARY OF BODY WEIGHT RESPONSE Day of study Control 222 EGBE (mg/kg) 885 443 0 235 17232 13 238 15 235 23 3 253 20 245 15 249 16 231 26 6 272 19 267 14 270 19 253 22 13 311 25 309 17 306 241 281 22 b.` … Please enable it to take advantage of the complete set of features! 2-Butoxyethanol is an organic compound with the chemical formula BuOC2H4OH. Sections I (Health Hazard Assessments for Noncarcinogenic Effects) and No evidence was found for excretion of 2-butoxyacetic acid, which has been shown to exert haematological effects in rats. EGME and EGMEA are efficiently absorbed by inhalation as well as via dermal penetration. The principal effect exerted by 2-butoxyethanol and its metabolite 2-butoxyacetic acid is haematotoxicity, with the rat being the most sensitive species. The maximum intrinsic clearance varied between 0.7 and 2.0 ml/min/g liver. Sakurai K, Mikamoto K, Shirai M, Iguchi T, Ito K, Takasaki W, Mori K. J Appl Toxicol. The glycol ethers methoxyethanol (ME), ethoxyethanol (EE), and butoxyethanol (BE) are widely used in industrial and house-hold products. 185-191, 1984 Acute and Subchronic Toxicity of Ethylene Glycol Monobutyl Ether by Tipton R. Tyler* The available information on the acute and subchronic toxicity ofethylene glycol monobutyl ether is The available information on the acute and subchronic toxicity of ethylene glycol monobutyl ether is reviewed. Following supportive treatment and haemodialysis the outcome was favorable. In a 90-day study, rats were exposed to EGBE concentrations of 77, 25, 5, or 0 ppm for 13 weeks (6 hr/day, 5 days/week). Acute toxicity values, such as oral and percutaneous LD 50 s, are often used as the basis for classifying chemicals into toxicity categories, and their subsequent regulation. Levels of airborne 2-butoxyethanol in occupational settings are typically in the mg/m3 range. . At ambient conditions, the low vapor pressure of ethylene glycol monohexyl ether (EGHE) allows for a maximum vapor concentration of approximately 85 ppm. CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): The available information on the acute and subchronic toxicity of ethylene glycol monobutyl ether is reviewed. For maternal rats at 79.2 ppm, there were transient decrease in body weight and body weight gain during exposure, reduced food consumption, increased water consumption, and excess lacrimation. The results support the hypothesis that EGBE is mainly metabolized via oxidation by alcohol dehydrogenase in the rat liver. Thus, exposure of rats and rabbits to EGHE vapor during the period of organogenesis produced maternal toxicity at near-saturation vapor concentrations (79.2 ppm), but no evidence for developmental toxicity or teratogenicity. Park J, Yoon C, Byun H, Kim Y, Park D, Ha K, Lee Sm, Park S, Chung E. J Occup Health. Within the dose range studied, the absorption and metabolism of these three glycol ethers by rats was linearly related to the dermally applied dose. 102, 443–455). cutaneous hypertensitivity, and all glycol ethers studied were classified from slightly irritant to severely irritant according to the Draize protocol, though only 2-butoxyethanol and isopropoxyethanol were classified as skin irritants with the EEC method. Studies on ethylene glycol alkyl ethers and related compounds administered to mice by oral gavage revealed the occurrence of testicular atrophy and decreased white blood cell count by EGM, … 2-Butoxyethanol Butyl cellosolve Dowanol EB Glycol butyl ether Poly-solv EB Call fire department. Possibly related to these findings in the liver were decreases in serum transaminases (aspartate and alanine aminotransferase) and sorbitol dehydrogenase, with an increase in alkaline phosphatase observed in the 71-ppm group of female rats. When substances were not noted as present in safety data sheets of cleaning products used but were measured, air concentrations showed no presence of MEA, while the glycol ethers were often present, and formaldehyde was universally detected. Data from animal studies have been examined from the standpoint of dose-response relationships and the sensitivity of various animal species, including man, to the effects of this chemical. 2-Butoxyethanol is readily absorbed following inhalation, oral, and dermal exposure. Toxicol Lett. 14C-DGBA was rapidly absorbed from the gastrointestinal tract and eliminated predominantly in rat urine within 24 h following oral administration at 200 or 2000 mg/kg. Based upon limited data, ambient exposures in air are generally in the μg/m3 range. It is liable to form peroxides on exposure to air and light. ETHYLENE GLYCOL MONOBUTYL ETHER EGM CAUTIONARY RESPONSE INFORMATION Common Synonyms Oily liquid Colorless Mild rancid odor Floats and mixes with water. The urinary tract of all animal species used in biomedical research may exhibit a variety of pathologic entities. Notify local health and pollution control agencies. The in vitro hydrolysis of DGBA in rat blood and its in vivo metabolism and disposition in male Sprague-Dawley rats were studied. In rats, adverse effects on the central nervous system, kidneys, and liver occur at higher exposure concentrations than do haemolytic effects. It is concluded that the available information continues to support the current ACGIH TWA8-TLV of 25 ppm with a STEL of 75 ppm. When applied to the skin of rabbits for 4 h, 2-butoxyethanol caused mild irritation; extending the period of contact increased the severity of irritation, ... EGBE appears more toxic than ethylene glycol monoethyl ether and ethylene glycol in animals, A growing body of epidemiologic evidence suggests an association between exposure to cleaning products and respiratory dysfunction. 2-Butoxyethanol has been assessed as a Priority Substance under the Canadian Environmental Protection Act. Although the results of in vitro tests for mutagenicity of 2-butoxyethanol were inconsistent, the absence of structural alerts and the negative findings from in vivo studies are sufficiently reassuring to allow the conclusion that 2- butoxyethanol is not mutagenic. Monitors for maternal toxicity were body weight, food and water consumption, clinical signs, and hematology. Personal air samples were collected in 12 cleaning companies, and analyzed by conventional methods. Based primarily on investigations in experimental animals, the critical health effects associated with exposure to 2-butoxyethanol are alterations in hematological parameters associated with hemolysis and lesions of the forestomach in mice. There were no treatment-related effects with respect to hematology, necropsy, or gestational parameters and no significant change in the incidence of malformations or variations (expressed as total, individual, external, visceral, or skeletal). Toxicol.6, 349–355.Adult male rats (Crl:COBS CD (SD)BR) were given undiluted ethylene glycol monobutyl ether (EGBE) by gavage in doses of 222, 443, or 885 mg/kg/day, 5 days/week over a 6-week period. The dermal LDââ value was found to be between 2 and 4 g/kg. They are used in paints, lacquers, stains, inks and surface coatings, silk-screen printing, photographic and photo lithographic processes, for example, in the semiconductor industry, textile and leather finishing, production of food-contact plastics, and as an antiicing additive in hydraulic fluids and jet fuel. Similar, but less marked, hematologic effects were observed in rats exposed to 86 ppm of EGBE, while rats of the 20 ppm group were indistinguishable from controls. Rodent studies indicate the ME and EE are potentially toxic compounds causing teratogenic, fetotoxic, hematotoxic, and testicular effects. 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